Induced asthma – Acute inflammatory model (7 days)

Model 1: Acute inflammatory model (7 days)

  • Description: Challenged with HDM by intranasal administration on days 2, 4, 6. Mice were sacrificed 24 hours after the last challenge.
  • Duration: 7 days.
  • Attributes: Acute inflammatory model.
  • Endpoints: Total and differential cell count in the BALF/Lung.
  • Material used: D. pteronyssinus extract from Citeq

Mice also received 1A8 (neutrophil depleting antibody) or 2A3 (control antibody).

The Citeq HDM extract induces a strong inflammatory response with a larger neutrophilic component than previously observed using the X extract. At 1A8 (neutrophil depleting antibody) dose previously optimized neutrophils induced by Citeq HDM extract are inhibited but not blocked.

All allergic asthma models

  1. Acute inflammatory model (7 days)
  2. Acute sensitization/ challenge model (14 days)
  3. Acute sensitization/ challenge model (17 days)
  4. Acute challenge model (21 days)
  5. New HDM (immuno)therapy testing (45 days)
  6. Sensitization/ challenge model (60 days)

Our HDM extracts