Induced asthma – Acute sensitization/ challenge model (17 days)

Model 3: Acute sensitization/ challenge model (17 days)

• Description: Sensitized with HDM by intranasal administration on day 0, followed by intranasal challenge at days 14, 15, 16 and 17. Mice were sacrificed 3 hours after the last challenge.
• Duration: 17 days.
• Attributes: Acute sensitisation/ challenge model.
• Endpoints: Total and differential cell count in the BALF/Lung.
• Material used: D. pteronyssinus extract from Citeq

Mice sensitized and challenged with HDM have an neutrophilic and eosinophilic response in both Lung and BALF. Treatment with HDM induces T cell (CD4+ and CD8+) and B cell response in both Lung and BALF.